Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain
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منابع مشابه
proteinuria is reduced by inhibition of inducible nitric oxide synthase in rat renal ischemia/reperfusion injury
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متن کاملUncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.
BACKGROUND Preeclampsia is a human pregnancy-associated syndrome associated with hypertension, proteinuria, and endothelial dysfunction. We tested whether increased reactive oxygen species (superoxide and peroxynitrite) production and decreased bioavailability of the endothelial nitric oxide (NO) synthase (eNOS) cofactor tetrahydrobiopterin (BH4) contributes to maternal endothelial dysfunction ...
متن کاملEndothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
AIMS Endothelial dysfunction is caused by reduced nitric oxide (NO) bioavailability and/or over-produced reactive oxygen species (ROS). The present study investigated a vascular benefit of AVE3085, an endothelial nitric oxide synthase (eNOS) enhancer, in preserving endothelial function in diabetic mice and the mechanisms involved. METHODS AND RESULTS Male db/db and db/m(+) mice were orally ad...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملNitric oxide synthase-dependent nitric oxide production is associated with salt tolerance in Arabidopsis.
Nitric oxide (NO) has emerged as a key molecule involved in many physiological processes in plants. To characterize roles of NO in tolerance of Arabidopsis (Arabidopsis thaliana) to salt stress, effect of NaCl on Arabidopsis wild-type and mutant (Atnoa1) plants with an impaired in vivo NO synthase (NOS) activity and a reduced endogenous NO level was investigated. Atnoa1 mutant plants displayed ...
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ژورنال
عنوان ژورنال: Aging and Disease
سال: 2018
ISSN: 2152-5250
DOI: 10.14336/ad.2017.0523